Botox and Fillers
Botox and Fillers in our center is provided by Ani Kalfayan, MD, who has over 10 years experience in cosmetic surgery.Botulinum toxin
Botulinum toxin is a medication and a neurotoxic
protein produced by the bacterium Clostridium botulinum. It is the most
toxic protein known with an LD50 of roughly 0.005-0.05 µg/kg. Despite
this, it is used in minute doses, in some parts of the world, to treat
muscle spasms. It is sold commercially under the brand names Botox,
Dysport, Myobloc, Neurobloc and Xeomin for this purpose. Botox Cosmetic
and Vistabel are available for cosmetic treatment. The terms Botox
(Cosmetic), Vistabel, Dysport, Myobloc, Neurobloc and Xeomin are trade
names and are not used generically to describe the neurotoxins produced
by C. botulinum.
The cosmetic effect of BTX-A was initially described by
ophthalmologist Jean Carruthers and dermatologist Alastair Carruthers, a
husband-and-wife team working in Vancouver, Canada, although the effect
had been observed by a number of independent groups (Brin, and the
Columbia University group). On April 15, 2002, the FDA announced the
approval of botulinum toxin type A (BOTOX Cosmetic) to temporarily
improve the appearance of moderate-to-severe frown lines between the
eyebrows (glabellar lines). BTX-A has also been approved for the
treatment of excessive underarm sweating. The acceptance of BTX-A use
for the treatment of spasticity and muscle pain disorders is growing,
with approvals pending in many European countries and studies on
headaches (including migraine), prostatic symptoms, asthma, obesity and
many other possible indications are ongoing.
Botox is manufactured by Allergan Inc (U.S.) for both therapeutic as
well as cosmetic use. The formulation is best stored at cold temperature
of 2-8 degrees Celsius. Dysport is a therapeutic formulation of the
type A toxin developed and manufactured in Ireland and which is licenced
for the treatment of focal dystonias and certain cosmetic uses in many
territories world wide. Neuronox is a new type A toxin manufactured by
Medy-Tox Inc (South Korea).Botulinum toxin
Despite Botulinum toxin being one of the most lethal naturally
occurring substances known to science, it is still widely used for
cosmetic purposes in a purified and isolated form.
Besides its cosmetic application, Botox is used in the treatment of:
* Cervical dystonia (spasmodic torticollis) (a neuromuscular disorder involving the head and neck)
* Blepharospasm (excessive blinking)
* Severe primary axillary hyperhidrosis (excessive sweating)
* Achalasia (failure of the lower oesophageal sphincter to relax)
* Local intradermal injection of BTX-A is helpful in chronic focal
painful neuropathies. The analgesic effects are not dependent on changes
in muscle tone.
* Migraine and other headache disorders, although the evidence is conflicting in this indication
Other uses of botulinum toxin type A that are widely known but not specifically approved by FDA include treatment of:
* Pediatric incontinence, incontinence due to overactive bladder, and incontinence due to neurogenic bladder.
* Anal fissure
* Spastic disorders associated with injury or disease of the central
nervous system including trauma, stroke, multiple sclerosis, Parkinson’s
disease, or cerebral palsy
* Focal dystonias affecting the limbs, face, jaw, or vocal cords
* TMJ pain disorders
* Diabetic neuropathy
* Wound healing
* Excessive salivation
* VCD Vocal cord dysfunction a spasming of the vocal cords
* Reduction of the Masseter muscle for decreasing the size of the lower jaw
Treatment and prevention of chronic headache and chronic
musculoskeletal pain are emerging uses for botulinum toxin type A. In
addition, there is evidence that Botox may aid in weight loss by
increasing the gastric emptying time.
JUVÉDERM is the smooth gel filler that your doctor
uses to instantly smooth away wrinkles around your mouth and nose. With
just one treatment, you’ll get smooth and natural-looking results that
last up to a year.
It is infused with lidocaine to improve comfort during treatment. With JUVÉDERM you get the smooth results you expect, with the improved comfort you want
Everyone’s skin ages differently and JUVÉDERM may be used to rejuvenate multiple problem areas.
From smile lines to vertical lip lines, you can smooth away unwanted
wrinkles and restore natural contours.